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pentobarbital will raise the amount or outcome of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers lessened ivosidenib plasma concentrations.pentobarbital will lessen the extent or outcome of brexpiprazole by influencing hepatic/intestinal